Glutamate excitotoxicity is likely a result of too much calcium (CA++) entering cell too rapidly
Of course Lewis, Ca++ is the more useful electrolyte to assay in neurotoxicity. Indeed, Mitochondria exert an important physiological function in regulating intracellular Ca2+ homeostasis and. mitochondrial dysfunction occurs in response to Ca2+ overload or ROS accumulation in a neurotoxicity process.
I agree with both my peers on excitotoxic signaling. From a clinica standpoint, we often tend to look at acidosis (or lactate levels as lactate is extruded with H+) during energetic crisis. What you measure will be as important as when you measure it as glutamate can be cleared, then re-released as transporters work in antiporter mode during energetic failure.
During Excitotoxicity, brain tissues & neurons becomes rich in Calcium intracellular, which is the main source of toxicity. Other electrolyte involved in lesser quantity compare to Ca2++
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