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Questions related from Lewis Alan Opler
Methylfolate has been shown to help SSRIs work better in patient with difficulty converting folate to methylfolate. Deplin is methylfolate and it is being widely used to augment SSRIs in partial...
09 September 2016 3,592 2 View
Others have provided compelling evidence that schizophrenia, like many chronic diseases, may in part be due to mitochondrial dysfunction. As a clinician, I am aware of the use of R-lipoic acid,...
23 May 2016 1,060 5 View
FROM WIKIPEDIA:Upon moving to become Professor of Clinical Psychiatry at the University of Munich in 1903, Kraepelin increasingly wrote on social policy issues. He was a strong and influential...
20 March 2016 5,770 15 View
I have seen several patients who take vitamin B12 as a supplement who have developed insomnia. I am trying to find evidence supporting causality.
19 February 2016 7,424 13 View
Animal models suggest it does but I am hoping to learn of clinical trials.
18 January 2016 9,071 4 View
Preclinical studies suggest carnitine and ALCAR should have antidepressant efficacy, but (to my knowledge) there is a paucity of clinical trials. i am hoping my RESEARCHGATE colleagues know of...
10 January 2016 2,949 1 View
While buspirone, venlafaxine, and duloxetine all help with generalized anxiety disorder, for patients in whom either efficacy is limited for these agents or side effects are not tolerable,...
14 December 2015 6,135 17 View
Ketamine has emerged as a rapid treatment for refractory depression. It has been suggested it may treat PTSD also.
09 October 2015 8,362 3 View
There is some limited evidence that intranasal oxytocin ameliorates postpartum depression. I am interested in publications, clinical anecdotes, personal reflections, etc.
21 July 2015 1,978 10 View
The benzodiazepines and zolpidem are fine if used as a p.r.n., but I find most patients at some point end up having weeks or months require p.r.n.'s, after which they are dependent on these...
13 May 2015 1,785 5 View
There are studies re: this off label use; I am interested in any first hand experience albeit anecdotal
28 March 2015 4,376 2 View
Sialorrhea is the fancy term for hypersalivation.
03 March 2015 4,139 14 View
When first conceptualized by Stanley R Kay and myself in 1980, we anticipated that the PANSS would be valuable as both a research and clinical tool (this is clearly stated in all versions of the...
22 February 2015 802 9 View
We use many agents "off label" (eg carbamazepine for bipolar) yet given history of abuse and psychotic reactions to both ketamine and phencyclidine we need to be cautious. In what situations...
20 February 2015 5,381 18 View
Woolley and Shaw (1954) noting the structural similarity between 5-hydroxytryptamine aka serotonin and LSD hypothesized that LSD somehow blocked the action of serotonin and that serious mental...
01 January 1970 665 3 View
