Hi,

As you know it depends on the Pka and pH of your media that your drug is solved.

Thank u for your answer. We used the DI water as the reaction media.

Dear Bozhi,

welcome,

would describe in more detail how do you fabricated the positively charged drug? So that one can discover how the material gets charged. In principle initially materials are neutral and they get charged by transferring charges to them or from them. If the material is positively charged means that we extracted electrons from its surface or added positive ions to its surface.

Best wishes

Dear Prof. Zekry,

Thanks for your reply. We coated the polypyrrole (PPy) film on the surface of a home-made needle by using electrochemistry workstation. Oxidation was reacted among the pyrrole monomer during the polymerization process. Finally, the fabricated needle is positively charged. Our purpose is loading drugs into the fabricated needle.

Best wished

It depends on pka and ph

Dear Mr. Bozhi

Most protein drugs carry both charges (insulin as an example carry positive and negative charge) and we can make it positive in acid media as it accept protons or negative in basic media as it loss hydrogen..so as a suggestion you can use of protein drugs to be carried on these needles in a suitable media.

I hope you all the best