ACE II catalyzes the conversion of decapeptide angiotensin I to octapeptide angiotensin II.
Dear Araz,
the pulmonary endothelium is known to be the main source of circulating ACE in the body. Main work in this field has been scientifically done by Sergeij Danilov and his group. However most of his work is on ACE I.
some papers:
Heterogeneous distribution of angiotensin I-converting enzyme (CD143) in the human and rat vascular systems: vessel, organ and species specificity.
Metzger R, Franke FE, Bohle RM, Alhenc-Gelas F, Danilov SM.
Microvasc Res. 2011 Mar;81(2):206-15. doi: 10.1016/j.mvr.2010.12.003. Epub 2010 Dec 16.
There is a work in mice which says that ACE II was primarily epithelial in the lung however:
Angiotensin converting enzyme 2 is primarily epithelial and is developmentally regulated in the mouse lung.
Wiener RS, Cao YX, Hinds A, Ramirez MI, Williams MC.
J Cell Biochem. 2007 Aug 1;101(5):1278-91.
best wishes
Kai
Dear collegue,
The reaction of conversion of angiotensin I is catalyzed by the converting enzyme to angiotensin II, which is located in small wells in the surface of endothelial cells of capillaries.
Dear Kai Novak
Thanks for your answer, I'll try to read The papers that you've mentioned above.
Dear Ioannis Sotiriou
Thanks for your answer, I appreciate your kindness
Dear Michael Roth
Thanks for your answer, I want to find out the ACE II Levels In acute lung injuries.
Thanks Prof. Roth
I send you a message containing details of my experiment. I would be happy to have your comments.
ACE, angiotensin I and angiotensin II are part of the renin-angiotensin system (RAS), which controls blood pressure by regulating the volume of fluids in the body. ACE is secreted in the lungs and kidneys by cells in the endothelium (inner layer) of blood vessels.
- Badges
- Science topic