Several natural products have reported for anti-HIV activity..please share some of them and drug molecules with its limitations in terms of bioavailability and side effects
polyphenolic compounds have confirmed effect in vitro. but in vivo, the things change.
You can review this reference:
Article Anti-HIV natural products
Vishnu Sankar
Interesting question and extremely pertinent. Please have a look on the following resources focussing on this issue:
1.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709506/
2.https://www.jstor.org/stable/24110574?seq=1#page_scan_tab_contents
3.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983620/
4.https://www.mdpi.com/journal/molecules/special_issues/Antitumor_Anti-HIV
5.https://juniperpublishers.com/jojiv/pdf/JOJIV.MS.ID.555556.pdf
6.https://www.intechopen.com/books/pharmacognosy-medicinal-plants/natural-products-in-drug-discovery
7.https://pubs.acs.org/doi/10.1021/np000399
8.https://www.liebertpub.com/doi/full/10.1089/aid.2017.0232
Obesity drug could help people with HIV
"People with HIV could benefit from semaglutide, the blockbuster drug marketed as Wegovy for obesity and Ozempic for diabetes. If early data about the treatment’s effects are confirmed, semaglutide and other drugs like it could become key to controlling the metabolic problems associated with anti-HIV medications. Studies presented last week at a conference suggest it helps people with HIV to lose weight and reduces certain conditions associated with fat accumulation that are especially common in people infected with the virus..."
https://www.nature.com/articles/d41586-024-00691-8
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