Whey rises insulin, and gives amino acids. AA's promote mTOR, while insulin would inhibit mTOR through pathways? How does this work?
It is claimed whey increases insulin and AA's. Insulin would inhibit mTOR through IRS1 -> PI3k -> PDK1 ->Akt/PKB -> mTOR inhibit.
AA's would promote mTOR. Furthermore mTOR would inhibit IRS1 through S6k.
So whey and muscle protein synthesis through AA's and insulin have both a promoting and inhibiting effect on mTOR?
You can benefit from the following links.
1. Drummond MJ, Bell JA, Fujita S, et al. Amino Acids are Necessary for the Insulin-Induced Activation of mTOR/S6K1 Signaling and Protein Synthesis in Healthy and Insulin Resistant Human Skeletal Muscle. Clinical nutrition (Edinburgh, Scotland). 2008;27(3):447-456. doi:10.1016/j.clnu.2008.01.012.
2. Yoon M-S, Choi CS. The role of amino acid-induced mammalian target of rapamycin complex 1(mTORC1) signaling in insulin resistance. Experimental & Molecular Medicine. 2016;48(1):e201-. doi:10.1038/emm.2015.93.
3. Peter Bond .Regulation of mTORC1 by growth factors, energy status, amino acids and mechanical stimuli at a glance.Journal of the International Society of Sports Nutrition201613:8
Since mTOR is involved in protein synthesis, it would be reasonable to think that growth factors may mediate its activation thourgh PI3K or PKB-mediated pathways. It seems to be so as many papers regard this. Here you have two good reviews by M-S Yoon (one of them was alredy suggested by Entedhar Sarhat) explaining mTOR and insulin crosslink.
Also, mTOR downregulates insulin signaling in a negative-feedback way. This is explained as mTOR is upregulated by nutrient signals, and excess of them is correlated to insulin impairment and resistence.
-Yoon M-S. The Role of Mammalian Target of Rapamycin (mTOR) in Insulin Signaling. Nutrients. 2017;9(11):1176. doi:10.3390/nu9111176.
-Yoon M-S, Choi CS. The role of amino acid-induced mammalian target of rapamycin complex 1(mTORC1) signaling in insulin resistance. Experimental & Molecular Medicine. 2016;48(1):e201-. doi:10.1038/emm.2015.93.
Best regards.
Sorry yes I printed a schematic overview but misread something :D thanks for the articles thoug
- Badges
- Science topic
- Similar topics
- Phytochemistry
- Extracts