Hi, is there anyone who wants assistance with interpretation and/or classification of mutations to determine possible causality?

While doing research on genes possibly involved in a specific phenotype, you can run in to several difficulties for the interpretation and classification of mutations found, consequently making...

09 October 2017 9,968 2 View

Is there a simple way to determine if a mutation introducing a premature stopcodon signals nRNA degragdation?

11 December 2014 967 6 View

Is there a database/source for dinosaur DNA and/or protein sequences?

I want to study specific protein sequences to better understand their functional properties. I think that such information from this group of animals may help in this understanding.

06 July 2014 8,506 2 View

Would it be possuible to determine why two homologous proteins show a high degree of species specificity for the same ligand?

If two proteins are known for there distinct functions, but show affinity for the ligand of at least one other between species (bovine>human), could this be analysed?

04 May 2014 2,061 5 View

What is or are the best bioinformatic tools to assess the structural and functional implication of a non-synonymous mutations in humans?

There are several tools available to predict such implication, but the why of using one or even more remains unclear to me. Does someone have an idea of "the best" methods to be used. Moreover, is...

03 April 2014 7,441 10 View

Protein-protein interactions: are there any reliable programs to predict interaction between proteins using homology-based molecular structures?

I want to know how two proteins of interst interact with each other by using their homology-based molecular structure. I know from experimental data which part of each protein is required for...

03 April 2014 2,878 11 View

Does anyone have some general info on non-coding RNAs?

I would like to get some key articles and/or presentations to help understand the underlying mechanism responsible that is responsible for transcription and their function.

31 December 2013 8,669 2 View

Looking for protein-protein docking software. Any suggestions and experiences?

Would like to get some assistance with simulating/estimating the interactions between two proteins to beteer understand structure-function properties.

09 October 2013 296 8 View

How to write a good grants proposal?

I want to continue my career in Academia in the field of bioinformatics.

09 October 2013 8,134 4 View

I want to be a reviewer for journals in bioinformatics and computational biology. Any options?

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09 October 2013 9,470 3 View

MD MOE RMSD

How to calculate the RMSD values for a MD simulation using MOE?

07 August 2021 0 0 View

MD MOE RMSD

How to calculate the RMSD values for a MD simulation using MOE?

07 August 2021 0 0 View

fatal error

When I tried to energy minimization my system, I got fatal error as below. Fatal error: Atomtype opls_116 not found Although I've already added this line: ; include water #include "oplsaa.ff/spc.itp" to [molecultype] directive in my topology.

16 June 2021 0 0 View

fatal error

When I tried to energy minimization my system, I got fatal error as below. Fatal error: Atomtype opls_116 not found Although I've already added this line: ; include water #include "oplsaa.ff/spc.itp" to [molecultype] directive in my topology.

16 June 2021 0 0 View

fatal error

When I tried to energy minimization my system, I got fatal error as below. Fatal error: Atomtype opls_116 not found Although I've already added this line: ; include water #include "oplsaa.ff/spc.itp" to [molecultype] directive in my topology.

16 June 2021 0 0 View

fatal error

When I tried to energy minimization my system, I got fatal error as below. Fatal error: Atomtype opls_116 not found Although I've already added this line: ; include water #include "oplsaa.ff/spc.itp" to [molecultype] directive in my topology.

16 June 2021 0 0 View

What kind of fluid could I use for a pitfall trap that also does not invalidate molecular testing?

Hi, I want to start testing pitfall trap to obtain ants samples, but I need to conduct molecular analysis on those insects. So, what kind of fluid can I use? Ethanol expires too early and I need...

03 March 2021 5,978 5 View

How to repeat an operation on an atom selection for multiple times in PyMol?

Hi, I am trying to construct a multi-layer fibril structure from a single layer in PyMol by translating the layer along the fibril axis. For now, I am able to use the Translate command in PyMol...

02 March 2021 4,569 4 View

New Journal, "Integrative Psychological and Behavioral Science" -- do you not know, and have you not seen, this done before?

Question to you and THEM, the New Journal, "Integrative Psychological and Behavioral Science" -- do you not know, and have you not seen, this done before? There appears to be a core problem for...

02 March 2021 3,024 2 View

Does anyone know HRM channel in a 2 plex QIAGEN Rotor- Gene Q qPCR can be used as a separate channel?

I am going to have 3 different probes in my qPCR work that I am going to do. But I realized that the machine we have in the lab is a Rotor-Gene Q 2plex HRM Platform, saying it has green, yellow,...

01 March 2021 8,544 1 View