Rene Mulder

14 Questions 51 Answers 0 Followers

Questions related from Rene Mulder

Hi, is there anyone who wants assistance with interpretation and/or classification of mutations to determine possible causality?

While doing research on genes possibly involved in a specific phenotype, you can run in to several difficulties for the interpretation and classification of mutations found, consequently making...

10 October 2017 10,032 2 View

Is there a simple way to determine if a mutation introducing a premature stopcodon signals nRNA degragdation?

I have recently found a mutation that leads to a premature stopcodon. I now want to know if this mutation could result in nonsense-mediated mRNA decay. Are there ways to do this?

12 December 2014 1,036 6 View

Is there a database/source for dinosaur DNA and/or protein sequences?

I want to study specific protein sequences to better understand their functional properties. I think that such information from this group of animals may help in this understanding.

07 July 2014 8,573 2 View

Would it be possuible to determine why two homologous proteins show a high degree of species specificity for the same ligand?

If two proteins are known for there distinct functions, but show affinity for the ligand of at least one other between species (bovine>human), could this be analysed?

05 May 2014 2,130 5 View

Protein-protein interactions: are there any reliable programs to predict interaction between proteins using homology-based molecular structures?

I want to know how two proteins of interst interact with each other by using their homology-based molecular structure. I know from experimental data which part of each protein is required for...

04 April 2014 2,946 11 View

What is or are the best bioinformatic tools to assess the structural and functional implication of a non-synonymous mutations in humans?

There are several tools available to predict such implication, but the why of using one or even more remains unclear to me. Does someone have an idea of "the best" methods to be used. Moreover, is...

04 April 2014 7,510 10 View

Does anyone have some general info on non-coding RNAs?

I would like to get some key articles and/or presentations to help understand the underlying mechanism responsible that is responsible for transcription and their function.

01 January 2014 8,729 2 View

Where to publish your data?

If you have data on phylogenetics, functional divergence and 3d structures, where should you publish it?

10 October 2013 4,463 7 View

I want to be a reviewer for journals in bioinformatics and computational biology. Any options?

10 October 2013 9,529 3 View

I want to know if the frequency of my mutation is higher/lower than reported by the snp-database. Should I compare it to the minor allele frequency?

This mutation was observed only heterozygous.

10 October 2013 6,453 3 View

How to write a good grants proposal?

I want to continue my career in Academia in the field of bioinformatics.

10 October 2013 8,203 4 View

Looking for protein-protein docking software. Any suggestions and experiences?

Would like to get some assistance with simulating/estimating the interactions between two proteins to beteer understand structure-function properties.

10 October 2013 362 8 View

I want to identify amino acid residues that are responsible for functional differences between paralogs. Any help?

There are several servers and software packages that address this question. However, DIVERGE (http://xungulab.com/pub.html) has been most succesful in determining such regions. Unfortunately, I...

09 September 2013 3,398 19 View

Does anyone have suggestions for phylogenetic analyses of a particular coagulation factor?

Step-by-step guidings would most helpful.

07 July 2013 1,313 6 View