Where does this information come from?

26 July 2017 1 10K Report

from uniprot : Nedd4 binds, in vitro, through the WW2 and WW3 domains, to neural isoforms of ENAH that contain the PPSY motif.

Martin Klvana

It is impossible to decipher the source of the information if none is provided by the authors. In some instances, such as this one, the database information is not very useful, and one has to perform an exhaustive literature search . . .

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As for the PPSY motif:

"Notch is ubiquitinated and destabilized by Nedd4 in a manner requiring the PPSYmotif in the Notch intracellular domain."

Article Drosophila Nedd4 Regulates Endocytosis of Notch and Suppress...

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