I know extracellular amyloid deposition begins around 2 months in the transgenic mice, first in the subiculum and layer V of the cortex. Also, Plaques are found throughout the hippocampus and cortex in six months.
However, I wonder which part is more faster between hippocampus and cortex?? If something is not the first, is it happening at the same time??
Additionally, how about the human brain?
Thanks a lot!
In general, and in mice model of FAD (such as 5XFAD) the expeditious emergence and development of A beta plaque deposition has been shown to be at hippocampal pyramidal and granular neurons in the CA1 and DG.
Some data has interestingly shown that even microglia derived from 5 week old 5XFAD mice can impede A beta plaque formation in vitro:
https://www.nature.com/articles/srep14624
Even though it would seem to be rather counterintuitive that cortical neurons can develop and deposit A beta plaques and NFTs earlier and faster than hippocampal neurons, there is not sufficient data to prove such rivalry! IHC and blotting data also have so far focused on hippocampal neurons as the cells that exhibit such deposition first.
It can also be inferred that the speed of AD-like symptom emergence and cognitive dysfunction is relatively higher in hippocampus compared to cortex in particular in primates and humans. I think that this can simply be explicated with regard to the smaller size and less neuronal density of hippocampus vs the cortical layers.
Hi,
You should read the Braak's work ! He is such a great human anatomist who contributed a lot on AD neuropathology.
Article Braak H, Braak E. Neuropathological staging of Alzheimer-rel...
Article Frequency of Stages of Alzheimer-Related Lesions in Differen...
Valentin
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