I read in papers that the (indirect) conversion of tyrosine to fumarate can take place in cells but I was wondering if this also takes place in the brain, specifically in neurons?
Tyrosine degradation is catalyzed by a series of five enzymatic reactions that yield acetoacetate, which is ketogenic, and the Krebs cycle intermediate, fumarate, which is glucogenic. The hepatocyte and renal proximal tubules are the only two cell types that express the complete pathway and contain sufficient quantities of all enzymes required for tyrosine catabolism.