Hello,
I am working on drawing a phylogenetic tree with samples sharing some somatic mutations.
The basic process of my work is similar to this article.
Article Population dynamics of normal human blood inferred from soma...
While studying this article and finding other tools that draw phylogenetic trees,
I found several tools.
https://vcf-kit.readthedocs.io/en/latest/phylo/
https://benbowlab.github.io/Phylogeny.html
etc..
But when I compared these tools with the article, I found a major difference.
In the article, they used simulations to draw trees and other supplementary methods.
But when using the tools, all I need was merged VCF files.
What is the difference between the methods?
Do these tools have a built-in simulation process?
Or the methods in the article is more accurate??
Thank you.
- Badges
- Science topic
- Similar topics
- Computer Science and Engineering
- Bioinformatics
- Bioinformatic Tools