During embryonic life the Pre Sertoli cells usually present a very variable shape of nuclei. I want to know weather the mitosis phase of spermatogenesis initiates at the time of puberty, or in the prepubertal period or in the embryonic life itself.
The process of spermatogenesis, which includes both mitosis and meiosis, begins before puberty. The key stages of mitosis in spermatogenesis occur during fetal development and continue through infancy and childhood, long before puberty begins. In the early stages of male development, during embryonic life and around the 9th week of gestation in humans, primordial germ cells migrate to the developing gonads (testes). These cells, known as prespermatogonia, represent the early germ cell population from which sperm cells will be derived.
Embryonic Development (Around 9th week of gestation) - Primordial germ cells migrate to the developing gonads, which in males will become the testes. These early germ cells are prespermatogonia.
Fetal and Prepubertal Period: Prespermatogonia differentiate into spermatogonia and undergo mitotic divisions. This mitotic activity starts during fetal development and continues through infancy, childhood, and the prepubertal period
The entire process is regulated by hormonal signals, primarily follicle-stimulating hormone (FSH) and luteinizing hormone (LH), which are released from the pituitary gland. These hormones stimulate the testes and play a crucial role in maintaining spermatogenesis.
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