It depends what kind of answer you want. If the question is about velocities of particles at impact then the answer is "yes". If the question is, as I am suspecting, whether the chosen spray parameters enable to obtain the coatings conform to specification, the the answer is "no". To find this answer, you would need also to model the particles temperatures and the growth of coating on given substrate. Conclusion is such that some experiments are always necessary.
So, if I would like to predict the in-flight or impact particles' temperatures and velocities, I can run a simulation. Otherwise, to obtain the optimal process parameters, I'll need additional modeling which takes the properties of the substrate into consideration as well as carrying out the required experiments.