I read some papers mentioning that they used the HMP reference genome for protein homology search and I've also read about the HUMAnN database elsewhere. I'm wondering what's the difference.
The HMP (Human Microbiome Project) database is a resource that focuses on characterizing microbial genomes and metagenomes in human body sites. It provides reference genomes for different microorganisms, aiding in the identification and study of microbial species. For example, HMP offers reference genomes for specific gut bacteria like Bacteroides fragilis, aiding in taxonomic classification and species-level analysis.
On the other hand, the HUMAnN (HMP Unified Metabolic Analysis Network) database and software tool are geared toward functional profiling of microbial communities. It leverages the HMP reference genomes to identify and quantify metabolic pathways and gene families in metagenomic data. For instance, HUMAnN can determine the presence and abundance of pathways like glycolysis or the nitrogen cycle, shedding light on the metabolic activities within a microbial community.
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