Avifavir is a favipiravir-based antiviral drug registered for treatment of COVID-19 in Russia. The drug has shown high efficacy in clinical trials, disrupting the reproduction of SARS-CoV-2. Favipiravir has been used in China to fight COVID-19.
Russia approved the first antiviral drug, Avifavir, which was produced in a joint venture by the Russian Direct Investment Fund (RDIF) and the ChemRar group. According to the developers, the drug can disrupt the reproduction mechanisms of COVID-19, and has shown "high efficacy in treating patients with coronavirus during clinical trials." A study revealed that the virus dies in an average of just four days when a patient takes the drug, compared to nine with a standard course of treatment.
In a non-randomized Chinese study in March, it was proved that Avifavir can clear the virus faster than an anti-HIV drug. Companies around the world are considering producing it, with Glenmark Pharmaceuticals currently conducting Phase 3 clinical trials in India that might be completed as early as July.
On June 11, the first batch of Avifavir will be delivered to hospitals in Russia. The drug will not go on sale and will only be used in hospitals under the supervision of a doctor. It will not be prescribed during pregnancy due to a possible effect on the fetus.
For the treatment of Covid-19, there are more than 150 drugs in circulation around the world. Avifavir is therefore just one drug among many others. However, Avifavir has been well approved to treat patients with the new coronavirus. Experts hope this new treatment will prove to be effective. The race for Covid-19 vaccines continues around the world. But no country, for the moment, has the miracle cure.
Avifavir is a favipiravir-based antiviral drug registered for treatment of COVID-19 in Russia. The drug has shown high efficacy in clinical trials, disrupting the reproduction of SARS-CoV-2. Favipiravir has been used in China to fight COVID-19.
Favipiravir is an oral antiviral approved for the treatment of influenza in Japan. It selectively inhibits RNA polymerase, which is necessary for viral replication. The drug was approved for the treatment of COVID-19 in the hospital settings in Russia on May 29, 2020, after an ongoing open-label randomized clinical trial had recruited 60 subjects on favipiravir.