From a research perspective, what aspects should future follow-up studies focus on?

This type of therapy has demonstrated significant tissue regeneration and repair capabilities in initial clinical applications, but whether the long-term efficacy can be stably maintained and how adaptable it is to different patient groups seems to require further verification. Especially in the context of chronic inflammation, can stem cells remain functionally active over long periods of time? In addition, immune rejection and potential risk of tumor formation after stem cell transplantation are key issues that remain. How do you think future research can improve efficacy while reducing risks by improving cell culture or delivery mechanisms? What specific biomarkers or imaging techniques are available to track efficacy and cell fate over time?