I have been using FSCVA for assessing fast dopamine fluctuations of dopamine in the rats brain in vivo. It would be good to analyse the same recordins or new ones on dopamin changes within minutes and hours. But changes in baseline currents and other factors influence the picture. I know the whole accepted way is the principal component regression. But it is too comlex for me to make it in practice. And I do not need absolute concentrations of dopamine, just changes. Are there any ather techniques, perhaps more simple? Or are there free soft for principal component regression?

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