I am currently working on MR diffusion model to monitor defects in human heart. Meanwhile, I am able to assume that diffusion coefficient is related to the relaxation rates (R1=1/T1 and R2=1/T2), I need experts to advise on which substance whose T1 and T2, I will have to use.
I need these features because the substance which is diffusing is expected to carry molecular signatures of the heart. Thank you.
I am a physician not a physicist, so I am sorry but I cannot help you.
If I understand correctly, you want to build a gel phantom that reflects the T1/T2/ADC characteristics of the myocardium ? If so, look into the following articles:
http://www.spandidos-publications.com/ijo/35/4/893
http://www.ncbi.nlm.nih.gov/pubmed/23576443
You will have to adjust the formulas to match T1/T2/ADC values of the myocardium. You can find T1/T2 in this paper:
http://dx.doi.org/10.1002/mrm.20605
And depending on the purpose of your study, you should look into papers reporting ADC values for in vivo or ex vivo. They can differ quite a lot! Finally you should validate your phantom with a gold standard technique for each characteristic value (T1/T2/ADC).
Good luck on all that
Thank you, Prof. Rapacchi. I have got the articles - going through them already!
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