Ideally the software would adjust the PET signal by tissue type and provide some normative values from healthy individuals.
Based on your topics of interest that you have listed, I assume you're looking at PET activity in the brain. I'll try to answer for that organ, specifically, but comment on general whole body use as well.
For the brain, I found that NeuroQ by Syntermed was uses robust means for internal normalization of activity and I believe it is FDA approved for cognitive and epilepsy applications with FDG. You can use the choice to normalize to the whole brain or the cerebellum and it uses T or Z scores that differ from a normal database. The GUI is one of the best for QC of your images and for accurate registration. For research it's great because it spits out a nice excel table with the raw and relative uptake values.
Outside the brain, the heart has many software packages available to it which also have normal database comparisons used clinically and in research. Corridor4DM, QPS to name a few.
For the whole body, I'm not aware of a suite that is able to automatically normalize by tissue type. Segmentation of the organs for this task is a work in progress and is something we do here at the NIH. What most people do is measure regions of interest in the blood or the liver as a background ROI. They then measure their target of interest to create a target to background ratio. It stands to reason that a computer could help out with this sort of thing, but I don't think it's available yet.
Best regards,
Just an add-on software from the previous answer could be the Analyze by the Biomedical Imaging Resource (BIR) at Mayo Clinic.
The only disadvantage is that it accepts images where the format has to be in Analize (.img and the respective .hdr).
Plus you have to create an object map of the brain for GM and WM in order to get concentration values.
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