It is known that rapid dissolution of orthopedic implants is dangerous. What methods are used to stop the rate of dissolution of magnesium (its alloy) in physiological solution?
The solubility is dependent on environmental factors like temperature, pH, magnesium is more sensitive to pitting corrosion. The inclusion of CO2 to the testing system lead to a more stable pH via the equilibrium of HCO3−/CO2 also promotes the formation of carbonate on the magnesium surface. Under aqueous conditions, the presence of CO2 results in the formation of a carbonated film, which is thicker than magnesium hydroxide film formed in the absence of CO2, resulting in slower corrosion. The increase of bicarbonate concentration in SBF from 4 (interstitial fluid content) to 27 mmol/L (blood plasma content) is proven to increase the passivity of the degradation layer and reduce corrosion. More details in the following references
Magnesium degradation under physiological conditions – Best practice https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935771/
Lindström R., Johansson L.-G., Thompson G.E., Skeldon P., Svensson J.-E. Corrosion of magnesium in humid air. Corros. Sci. 2004;46(5):1141–1158.
Xin Y., Hu T., Chu P.K. Degradation behaviour of pure magnesium in simulated body fluids with different concentrations of HCO3. Corros. Sci. 2011;53(4):1522–1528.
Thank you Dr. Gedvidas Bikulcius for your very intersted question.
The most currently research methods used to stop( mitigates) the high corrosion rate problem of Mg alloys are:
Ceramic materials coating on Mg alloys is highly potential candidate for bone tissue engineering [1][2] .
Biodegradable magnesium-matrix composites (BMMCs). The commonly used reinforcement phases for BMMCs divided into calcium phosphatebased bioceramics, silicon-containing bioceramics, magnesium oxide, and carbon material [3] [4].