Very earlier stage sodibicarb / sodium-bicarbonate was used to reduce gasrities

/ hyperacidity .

Antacid - A combination of Aluminium Hydroxide , Magnesium Hydroxide & Simethicone - An absorbent as well as adsorbent of Gastric as well as neutralise

acidity of stomach - To maintain the proper pH of stomach wall .

To reduce G.I reflux -

REF : https://www.medplusmart.com/product/RIFLUX-FORTE-TAB/RIFL0002

H2 - Receptor blocker - Ranitidine group of drugs - But prologed and excessive use

may cause cancer ?

REF : https://www.healthline.com/health-news/fda-warns-zantac-may-have-carcinogen

Rantidine dosage varies from 150 - 300 mg .Antiulcer and anti gastric agent .

https://www.medicalnewstoday.com/articles/321138

http://www.herbalremediesinfo.com/best-natural-cure-gastritis.html

https://www.healthline.com/health/home-remedies-for-gastritis

Thanks to Stephen I. Ternyik for your valuable links . Yes natural remedies or home remedies have less side effect than Schedule -H medicines .

Prologed gasritis will lead to G.I ulcers . So endoscopic examinations are carried

out by Gastro-enterologist Doctors . The most dangereous is H.Pylorie infections

leading to Gastric and deodenal cancer . So care should be taken from early stage.

With excessive acidity a vomiting tendency will appear - called G.I reflx disorder .

One of the major cause of Gastrities is Stress / Anxiety / Sleepless ness . Rat-racing in life will increse the risk of this global problem day by day .

Thanks for sharing the informations with us, they were very informative

Thanks to Dhifaf Zeki for your support .

Endoscopic View of G.I ulcer :

REF : en.wikipedia.org ( Image Source )

Severe acidity will cause burning sensation in stomach , contineous sour taste on

tongue as well as heartburn . Indistion due to disturbed bile secretion - Gall stone

prone .

The Biochemistry of Severe Acidity - the pH of stomach is controlled by Henderson eqn for Buffer . The secreted acid with enzyme Pepsin , Renin along with bile salt helps in digestion . But acidity disturbs the buffer capacity of Gastric

juice and hence the acid - enzyme disorder .

Now looking back to Hender eqn. pH = pKa + ( [ Salt ] / [ Acid ] ) . Here pKa value is interesting for strong acid -weak acid mixture . Here acid is not pure hydrochloric acid 100 % but a mixture of weak acid - salt . [ salt ] & [ Acid ]

are molar concentrations of salt & acid respectively .

Drink more normal water

Dear Siddappa Naragatti ,

In nathuropathy I think hydro-therapy .

I advise you to drink apple cider vinegar with water all your problems will end in one sentence

Yes Dr.Osamah K.Abdulretha Alsharifi it will be a good naturopathic treatment thru buffer actions .

Jaydip Data ji ya its hydrotherapy

Lots of water should be taken

Next generation antiacidity drugs - Proton Pump Inhibitor ( PPI ) .

Pantaprazole Grs of Drugs .

Omeprazole - Another very effective anti-ulcer drug .

The main cause of acidity is acid reflux disorder . The gastric hydrochloric acid -

enzyme mixture rises from reverse direction ie from stomach to mouth - called

G.I reflux .

To reduce this type of G.I reflux Domperidone may be used . A good combination

with Pantaprazole , Omeprazole even Ranitidine .

Methyl polysiloxane grs likely called MPS - Common antacids are called .

But the problem is acid resistant properties of Proton Pump Inhibitor ( PPI ) - So

developent of newer generation like Esomaprazole grs of drugs ie API is Esomaprazole -Mg .Very effective agaist Gastric ulcer with reflux diseases .

Pharmacology of PPI model -

REF : https://www.medicinenet.com/proton-pump_inhibitors/article.htm

Rabrazole - also an Anti-ulcer drug widely used .

REF : https://www.drugs.com/mtm/rabeprazole.html

GERD - Gastro Esophegal Reflux Disease - Very dangerous old & chronic Ulser .

H.Pylori induced G.I ulcer ! - It should be timely controlled .H.Pylorie kit should be

immediately taken as per supervision of consultant gastroenterologist .

Clarithromycin , Trinidazole & Pantaprazole - H.Pylorie kit .

REF : https://www.ncbi.nlm.nih.gov/pubmed/9421124

From chronic acidity /gasritis - other gastrointestinal problems like ameobiosis will occur or reverse .

GERD - The main cause of IBS - Irritable Bowel System - Contineous burning sensation in stomach / atonic constipation . Very painful and G.I discomfort -

Chronic problem - no way to releif without PPI & Domperodone ( sustained release ) grs of medicines .

Acid Gastric disorder - Combined with ameobiosis will cause Hepatic disorder

also .

Pantaprazole - levosulpride combination often used today agaist IBS .

Cold milk

ITOPRIDE - most widely used drugs used against IBS .

Dear Shrikaant Kulkarni ,

Cold / Chilled milk was used but modern gastroenterological consultation - Milk

product is completely prohibited . Since the MELOTONIN content in milk will form

complex with Ca . To digest this Ca-melotonin complex more acid secretion will

occur - Resulting GERD ulcer .

With the medicines widely used GERD -IBS syndrome - More and Fibrous diet like Isab -gul husk , wheat grass grain are used with plenty of water . Fibre will minimise constipation - as a Gasritis may be controlled .

REF : Manufacturer- PIRAMOL HEALTHCARE LTD .

Of course the most recommended are the PPIs

Dear Dr. Luis Rodrigo ,

Thanks for your apppropiate response !

Cold milk

Dear Charos Toshtemirova ,

Sorry Cold milk is not at all effective - as discussed my earler answer .

Night hipersecretion wery good improved with H2RA, for short time of 2 weeks, due to tachiphylaxia. Is good to known mechanisms of acidity hypersecretion (G, M1 or H2 mechanism).

Dear Zaim Gashi ,

Thanks for your Pharmacological Response !

Antacids must be also taken into account as symptomatic and quick relieve in the major part of cases

Dear Dr. Luis Rodrigo ,

Yes but a prologed dosage of antacid with instant change in Gastric pH will create

a majour didestive problem !

E.g. If is in question PUD, especially with bleeding, is wery import that pH to stay approximately 6, this increasing of pH is not possibile with antacids or with H2RA but only with PPI.

Hmm ! dear Zaim Gashi ,

From pharmacological standpoint it is right !

Regarding dietary protein intake Animal Protein should not be preferred - Due to

indigestion gasritis /acidity will increase .

take a look back for details -https://www.researchgate.net/post/What_do_you_prefer_to_take_ANIMAL_or_VEGETABLE_protein_and_Why

Gastritis is related to hepatitis - https://journals.lww.com/jcge/fulltext/2004/10000/Autoimmune_Gastritis_and_HCV_Chronic_Hepatitis__A.27.aspx

Prolonged acidity & Indigestion - A symptom of Gall-Stone !

Some medicines - like acetyl salicylic acid ( Aspirin ) -widely used in headache will

produce free salicylic acid in stomach induced acid-peptic ulser .

The simples and best waiy is to use omeprazol as protector

Yes @ Luis Rodrigo - I agree with you . Capsules are avaible in 20 -40 mg dosage .

With PPI some drugless therapy may be used to reduce mental stress - A root cause of Acid -peptic disorder !

https://www.researchgate.net/post/How_Drugless_therapy_helps_us_to_Improve_our_health

Exist some disorders that cause PUD such as polycythaemia rubra vera, Hyperparathyreoidismus, mastocitosis and others.

Their treatment for eventually exist of PUD is ethiologic treatment in the first line, and different PPI s for PUD treatment, in the second line.

Dear Zaim Gashi ,

I appreciate your lines of treatment regarding PPI .

Dear Jaydip Datta

Thank you

Gastric cancer due to Gasritis -

As per American Cancer Society - https://www.cancer.org/cancer/stomach-cancer/causes-risks-prevention/what-causes.html

The 3 classes disponible are antacids, H2-receptor antagonista and PPIs, Dependind of the severity you can choose the most conveniente for every patient

Domperidone - A widely used combination therapy with PPI grs like Omeprazole ,

Pantaprazole , Rabi& Esomeprazole anti-ulser drugs . Generally 30 mg is used of which 10 mg instant & then 20 mg in Sustained Release ( SR ) formulation .

Dependently from acid release mechanism, e.g for inhibition of M1 receptors, is need to administration PIRENZEPIN, for H2 receptors H2RA agents suc as Ranitidin, Famotidin, Nizatidin and generaly inhibition with different class of PPIs.

For Zollinger Elliosn Syndrome, high dose (double dose of PPIs).

All inhibitors of the proton pump are highly recommended

Dependently from ulcer location, is not need deep acid inhibition, e.g. ulcers in dhe cardia, wichs are associated with hypochlorhydria.

PPIs are more potent also other partial inhibitors.

All the best.

Natural anti gasritis drug - Indian Pudina is an excellent gas remover . Indian ayurvedic / herbal Mfg are formulating soft " Pudinhara " tablets .

Rabeprazole fastCombination of Rabeprazole , Domperidone with Sodibicarb power is an excellent formulation for both PPI along with gastric pH control .

Antacids, anti-H2 receptors, and IBPs, alone or in some cases in combination depending on the severity

Not only all the above medicines but main cause of ulser is "stress " also called Stress ulser so some natural remedies like Pranayana , Sabasana , Meditation ,

light music can remove this stress . We all should practice also regularly .

The natural remedies are much fewer effective than medical drugs, of course

Dear Luis Rodrigo ,

Being a chronic pateint of gastric ulser for the last 25 Yrs under PPI with domperidone with tranquliser as prescribed by my doctors , I have tried sabasana

with all these above to redure stress / anxiety . I am observing now the effect of

meditation . Let us see .

I agree with Luis

Dear Ghufran Aljuburi ,

Being a chronic gastric pateint of Gasrities for the last 30 yrs I have experianced all kinds of PPI , H2 blockers , Antacids but along with that medicines Indian Yoga

is a good stress reliever . Stress is the primary cause for acidity reflox .

Climate change ie from City to a Green Village will reduce the pollution level / ie the Gasrities .

Drinking water plays an important role towards gasritis - High Fe ( II ) content , Hardness , As , Hg ,& lead in ppm will be directly resposible for Gastric disorder .

Genetic factor has very import influence.

Genetically, increasses of parietal cells (mass of parietal cells) implicated and increasses of gastric acidity.

Zollinger-Elliosn Sy is caracterized with hypergastrinaemia, hiperacidity and diarrhoea.

Other, Mastocitosis also get with hyperacidity.

Very Important to know about your DW -

https://www.medicalnewstoday.com/articles/314886.

GERD - Itopride is a potent drug used in IBD resulting from Gasritis .

Endoscopic Biopsy is an important medical procedure to detect H.Pylorie infection for GI ulser leads to ultimately GI Carcinoma .

Peptic ulsur associated with H.Pylori infection - REF : slideshare.net ( Image Source )

Article Pathogenesis of Helicobacter pylori Infection

NSAID - Prolonged use will cause peptic ulcer -Article Helicobacter pylori infection and peptic ulcers

The eradication of H. Pylori is the best treatment for the cure of duodenal ulcer and chronic active gastritis

Maybe, antihelicobacter vaccina to be first choice in the future for the best treatment of this infection, due to increasses of antibiotic resistence.

Dear Luis Rodrigo & Zaim Gashi -lot of thanks for your contineous attachment - Do

you believe long fasting may cause gastric & deodonal ulcer ! - empty stomach ,food habits can help to prevent gastric ulcer .

ITOPRIDE - An Acidity IBD symptoms associated with G.I reflux - Article Effect of itopride, a new prokinetic, in patients with mild ...

LEVOSULPRIDE - formulalated with PPI - Functional dyspepsia - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1936295/

Prokinetics are not recommended in the medical treatment of burning and acidity

Refluxive problems are indication for procinetics, but not as first drugs.

Is need for attention due to cardiac side efects e.g. by cisapride but and Domperidone such as arrchythmia.

By grade LA/C and D especially, PPI are cornerstone for treatment of ARD.

Is need treatment with strategy: "step-up" or "step-down". I belive that is clear.

PPI

Dear Dr.Zaim Gashi ,

If you clear me the term LA /C and D ?

This is International Clasification for Gastroesophageal Reflux Diesease, named

LOS ANGELES A to D.

Is clear now ...

Thanks.

Thanks to Dr. Zaim Gashi ,

for his Los Angeles nomenclature system of G.I reflux disease .

Thanks from you, Mr Jaydip

Levosulpride - An IBS soother - https://www.1mg.com/generics/levosulpiride-rabeprazole-402134

It is very interesting featute that the Levosulpride is an Levorotatory ( - ) optically enantiomers - Article Pharmacotoxicological aspects of Levosulpiride

Antipsychotic - https://www.practo.com/medicine-info/levosulpiride-163-api