Solubility and drug absorption in gastrointestinal tract is increased by supersaturation of drug in GI fluids. How can we maintain supersaturated state and without getting the drug being precipitated?
It changes from compound-to-compound. You should be able to estimate the possible interactions that can be between the polymer and drug of your choice, knowing their chemical structures. I'll cite from the paper attached:
"In supersaturable formulations, drug concentration exceeds equilibrium solubility when formulations are exposed to the gastrointestinal fluids. In principle, high drug concentrations lead to an increase in oral absorption. However, since drugs are thermodynamically unstable at high concentrations, they have a tendency to precipitate rapidly in vivo before being absorbed, resulting in compromised bioavailability. Therefore in designing the supersaturable formulations, it is essential to maintain drugs in supersaturated concentrations in vivo by preventing drug precipitation before absorption"
There is also another interesting article that may be in interest of yours:
"Evaluation of gastrointestinal drug supersaturation and precipitation: Strategies and issues" by Jan Bevernagea, Joachim Brouwersa, Marcus E. Brewsterb, Patrick Augustijnsa in 2013 in the "International Journal of Pharmaceutics".
If you can't reach the attached or written articles, please state so, so that I can send them to you.
I hope it helps you with your problem.
Cheers
Article Drug Precipitation Inhibitors in Supersaturable Formulations.
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