As zeta potential gives idea about stability of the emulsion which is produced in GIT. Is high stability required inside the GIT? I found various opinions on this. In one journal the formulations having least zeta were chosen as optimized one and in the other formulations having highest zeta were chosen.
Zeta potential can give an indication about stability but can also be very misleading. e.g, if your stabilizing mechanism is steric and not electrostatic, then zeta potential may be of no relevance at all. You also have to take into account how the emulsion will interact with the interfaces in the GIT.
So, it depends!
What are the differences between the two formulations in the journals?
Try to optimize the formulation of drugs depending on pH of GIT
Article Intraluminal pH of the human gastrointestinal tract
Article Measurement of gastrointestinal pH profiles in normal ambula...
Article Gastrointestinal pH and Transit Time Profiling in Healthy Vo...
Hi,
Please note the following section of our recent publication:
2.3.1. Zeta potential and nanoliposome stability
Understanding the distinct colloidal and interfacial phenomena associated with the applications of nanovesicles requires knowledge of their ZP. Furthermore, knowledge of the ZP of a nanoliposome formulation can help to predict the fate of the formulation in vitro and in vivo. The magnitude of the measured ZP can be used to predict the stability and shelf-life of the nanoliposomal sample. If the nanoliposomes in a suspension possess a large negative or positive ZP then they will tend to repel each other and resist the formation of aggregates. However, if the phospholipid vesicles have low ZP values, i.e. close to zero, then there will be nothing to prevent the particles approaching each other and aggregate or fuse [41].
From:
M. Danaei,
M. Kalantari, M. Raji,
H. Samareh Fekri, R. Saber,
G. P. Asnani,
S. M. Mortazavi,
M. R. Mozafari, B. Rasti,
A. Taheriazam.
Probing nanoliposomes using single particle analytical techniques:
effect of excipients, solvents, phase transition and zeta potential.
Heliyon 4 (2018) e01088.
doi: 10.1016/j.heliyon.2018.e01088
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