I want to work on oral cancer detection. For that purpose I need to know, what the difference between a normal cell and a malignant cancer cell in oral cavity. If anyone knows, can you please reply?
Oral membrane mucus undergoes a temperature increase associated with head and neck cancers; particular during treatment.However, this difference is only slight. However, for oral cancers, such a temperature selection may be impossible to detect.
@arthur, temperature is not a constant in any organism; various regions have different temperatures;concept called regional body temperature. Adiposity and other factors can impact temperature in a region. In humans, anal temperature is not the same as temperature in the brain. Tumor microenvironments may have different temperatures.
The concept you are thinking of is "core temperature"
@Michael Mannen: Is the variation between normal tissue and malignant tissue is above 1 degree Celsius ? or less than that? I am asking about the temperature difference between malignant cell and near by normal cell. Anyway we know the normal temperature of human body is 36.8 degree Celsius. Similarly is there any specification for malignant tissue temperature? I saw in some publications that cancerous cell temperature is greater than 1 degree celsius with normal temperature. I just want to make sure is it correct or not. If temeprature difference is above 1.5 degree celcius, then only I can move forward with this research .
So can please give reply?
@Manu. Evidence indicates that temperature in tumors can be variable. The study attached indicates that some parts of tumors had higher and lower temperatures than rectal temperature, or core temperature; most sections of the body have temperatures similar to core temperatures.
Limited temperature increases in tumors during treatment can been seen as an avenue for treatment resistance.
http://cancerres.aacrjournals.org/content/46/12_Part_1/6229.full.pdf
@Michael Mannen: Thank you for your reply.
So the cancer detection based on temperature difference of benign and malignant cells will not help for detection..Is it ?
I think the temperature difference between normal and cancerous cell is between 1 & 2 degree in most cases. similarly the threshold temperature for both cells is also different and this concept is being utilized in photo thermal therapy as the cancer cells die by slightly increasing the temp & pH while the normal cells don't.
The temperature difference between cancerous and normal cells could be variable. Although there is this common concept that tumor cells tend to have slight increase (maybe 1 degrees celsius). Similarly with the manipulation of the cellular processes by the cancer cells, a major temperature and pH change within the tumor micro environment could easily effect them which is not usually the case in normal cells as they is a buffering system to protect the cells. So yes there is atmost 1-2 degrees difference between the cancerous and normal cells as usually quoted in literature
Dear all, I am very much interested by your discussion. Would you have a paper reporting temperature difference between cancer cells and normal cells ? Many thanks. Best, Geraldine
- Badges
- Science topic
- Similar topics
- Physical Sciences
- Waves