Has anybody administered MK-2206 (an orally active, allosteric inhibitor of AKT) intravenously to the mice?

We aim to use MK-2206 to inhibit AKT in mice. However, a large body of studies suggests that it should be administered orally. I was wondering if somebody could tell me that is it toxic for the...

07 February 2021 6,340 1 View

Which are the appropriate solvents for n-hexane plant extract for in vivo animal models to avoid toxicity?n-hexane plant extract is not soluble?

My n hexane plant extract is not soluble in any solvent. I have tried water, normal saline, tween 20 (2%, 5%, 10%, 50%), tween 80 (2%, 5%, 10%, 50%), pure DMSO, ethanol (2%, 5%, 10%, 50%, 97%),...

16 January 2021 3,547 3 View

What are the easy methods or techniques to synthesize green nano particles?

because many technical steps are there to get a particular plant nano particle and its expensive too

14 January 2021 1,556 4 View

What are the primary defects associated with welding druring construction-stages which might influence the capacity of the gusset-plate connections??

Dear researchers What are the primary defects associated with welding druring construction-stages which might influence the capacity of the gusset-plate connections in concentrated braced frames?...

06 January 2021 797 3 View

Which are the Non Small Cell Lung Cancer markers?

I would like to sort from a fresh specimen of lung cancer Non-Small Lung Cancer cells and cancer-associated fibroblasts to establish two different cell cultures. Which markers should I use? Thank...

04 January 2021 7,986 3 View

What is the new protocol followed by the World Health Organization to treat Covid 20?

The new strain of Covid 20 has spread in Britain, what is the new protocol for treating it, and is the old protocol followed by the World Health Organization suitable for treating the new strain...

21 December 2020 2,081 4 View

How can we convert powder (inorganic complex) in to a crystal?

I have powder (inorganic complex) and I want conversion it to crystal

03 December 2020 8,777 3 View

Can we use Google Form as our Research Tool?

I am confused regarding using Google Form as the questionaries tool for my study. It's effective during the covid-19 period but I didn't know if it is reliable or not. Please give your valuable...

18 November 2020 5,005 8 View

Can ELISA test be performed on whole blood?

Want to perform ELISA on whole blood instead of separating serum

03 October 2020 2,827 4 View

What is the difference between ultra-high vacuum chamber and edwards vacuum coating unit if we are using the the technique of thermal evaporation ?

developing thin films in ultra high vacuum chamber thermal evaporator.

09 September 2020 4,172 3 View

The reason of PMMA channels cracking?

07 February 2021 3,663 2 View

Lift off problem with Indium/Gold deposition?

Hi, I'm doing 5/40nm In/Au e-beam evaporation at rates 0.2A/s(for In),1A/s(Au) on lithographically(doubly coated 495k,950k PMMA e-beam resist) done Si substrate at base pressure 2e-6torr. I'm...

18 January 2021 7,550 4 View

How to choose a PMMA with the correct thickness IN E BEAM LITHO?

I try to pattern the gold layer around 2 nm-20nm on silicon, I used around 2000nm thickness (PMMA 950K A13), I tried to pattern five samples in total, but only one showed the pattern I wanted. I...

13 January 2021 7,710 1 View

Is surface embrittlement unavoidable after spray coating with brittle powder ?

I am not an expert at materials science. However, when I look at the literature, I read a process called cold spraying. This process is basically spraying a ductile powder (e.g. copper) onto a...

07 December 2020 5,378 2 View

Why is my TiO2 sol milky?

@Krunal Dholiya has sent me this question which I post below so he can get the benefit of many experts. Dear, I am preparing a thin film using TiO2 sol but i m fasing problem, with time it is...

23 November 2020 1,188 2 View

How to make few mm (~4-5 mm) thick Poly(methyl methacrylate) film?

Hi, I'm aware that thin film of PMMA can be spin coated. But I'm more interested in making few mm thick PMMA which will act as a substrate. Please share your expertise on how this can be...

21 November 2020 4,561 10 View

What could I expect to happen if I dilute a solution of PMMA in chlorobenzene with acetone?

I received a bottle of PMMA in solution with no information about which solvent was used, so I started using acetone to dilute the original solution. I had not experienced any consequences or...

03 November 2020 4,065 4 View

How to make CAB/PMMA polymer blend?

I need to synthesis CAB/PMMA polymer blend. Please tell me how to do it.

19 October 2020 9,843 3 View

Help me about swelling behavior of graphene oxide nanocomposites with methyl methacrylate with different proportions of GO?

Swelling behaviour of PMMA with GO contents 0.1%, 0.2,0.3,0.5?

02 October 2020 2,655 3 View

Any organic sacrificial material withstanding 1165 (heated) or acetone?

I am using E beam lithography for patterning which utilizes PMMA as the mask. I have a sacrificial layer coated with a thin SiN film, on top of which I need to pattern. Problem is when I try to...

22 September 2020 2,689 2 View