What is the stability of Chitosan nanoparticles? And how to increase the stability?

Hello Mohd Ashraf Malik ,

Your question was insightful.

According to my knowledge, Chitosan nanoparticles can be susceptible to aggregation and instability over time, which can lead to an increase in particle size. However, there are several strategies you can employ to enhance the stability of chitosan nanoparticles:

Surface modification: Modifying the surface of chitosan nanoparticles can improve their stability. This can be achieved by introducing stabilizing agents or polymers onto the surface, such as polyethylene glycol (PEG) or surfactants. These surface modifications can provide steric stabilization and prevent particle aggregation.

pH adjustment: Chitosan is a pH-sensitive polymer, and its stability can be influenced by the pH of the medium. In some cases, adjusting the pH to a more favorable range can help increase the stability of chitosan nanoparticles. For example, maintaining a slightly acidic pH (5-6) can prevent particle aggregation and stabilize the system.

Crosslinking: Crosslinking chitosan nanoparticles can enhance their stability. Crosslinking agents like glutaraldehyde or genipin can be used to create intermolecular bridges between chitosan chains, resulting in improved particle stability and reduced aggregation.

By employing these strategies, you can increase the stability of chitosan nanoparticles and mitigate issues such as particle aggregation and size increase over time.

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This article should be helpful and clear up any doubts. Wishing you success with your research Mohd Ashraf Malik !

Best wishes and regards,

Vishwajit Chavda

Alireza Sarkar Lotfabadi

To achieve enhanced stability and reduced size using the Ionic gelation method over a period of approximately one month, please consider the following instructions:

Utilize low molecular weight Chitosan.

Prepare a Chitosan solution with a concentration of 2mg/ml.

Prepare a TPP (Tripolyphosphate) solution with a concentration of 1mg/ml.

Maintain a volume ratio of 5:2 ml between the Chitosan solution and the TPP solution.

Simultaneously add the TPP solution and the Chitosan solution to the base medium.

Employ a stirrer set at 800 rpm while gradually dropping the solutions into the base medium.

Allow the mixture to stir and remain at room temperature for a period of 24 hours.

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