What is the solubility of NaOH in DMF at RT ?

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Carlos Araújo Queiroz

Vigorous reaction may occur with dry heated solvent. ― Perhaps of some interest and quoted from reference below: «Information has been published that a combination of dimethylformamide with sodium hydroxide represents a great risk of a reaction with uncontrolled exothermal course, especially if the reaction is conducted in a larger scale or if the reaction is heated» (*).

(*) K. Kaminska, I. Cerna (Zentiva, K.S.), "Process for the preparation of ceritinib using "in situ" prepared 5-methyl-2-(1 -methylethoxy)-4-(4-piperidinyl)-benzenamine monohydrochloride (1 :1 ) as an intermediate", WO 2017/041771 A1, 16 March 2017; apud: Buckley, J Chem Eng News, 1982, 60(28), 5; De Wall, G. Chem. Eng. News, 1982, 60(37), 5.

Greg Petruncio

NaOH reacts with DMF overtime to produce dimethylamine. Is there a particular reaction you are trying to do?