When a ROI is placed on lesion, Emaximum, Emean, Eminimum, Standarad deviation and diameter is caluated automatically. Please highlight the importance of calculating standard deviation in the Q-box.
I think that standard deviation calculate on the whole area of a focal lesion (thyroid, breast, and so on) is expression of the homogeneity of the stiffness of the tissue : low SD - almost homogeneous stiffness, high SD - very inhomogeneous stiffness (much higher risk of malignancy). In general you cal find even 'soft cancer', but 'homogeneous cancers' are not frequent!
The other feature very important in my experience is the stiffness ratio, calculated over the Whole nodule Vs. similar dimension ROI in the normal parenchyma (to be compared also in the SD value).
I believe that the best accuracy can be achieved only if the features taken in account are the ones of TI-RADS with the stiffness info and vascular features (density, morphology and distribution of the vessels).
In this is the triumph of the full multiparametric nature of advanced technology US.