Lycopene, carotenoids, Vitamin C, Oxidative stress, Free radicals, Leukoplakia, oral lichen planus, oral submucous fibrosis, oral cancer.
Antioxidants fight against the free radicals and helps prevent the potentially malignant diseases. These are naturally present in many vegetables and fruits, for example lycopene in tomato.
Chemoprevention is defined as the use of drugs or other natural, synthetic, or biologic agents to
inhibit, delay, or reverse the stepwise carcinogenic progression to invasive cancer.
● Retinoids are a well-studied class of chemopreventive agents. They have offered promising data
on their effects in reducing oral leukoplakias, in lowering second primary cancers, and in delaying
recurrences. Further trials are underway to validate these fi ndings.
● Numerous agents are in trial to identify those that prove to be effective and demonstrate low levels
of toxicities and evoke good patient compliance.
● Recent investigations have emphasized the need for molecular and genomic (surrogate) biomarkers
that can serve as intermediate end points.
for more details ,please read chapter 6 of very good book calledEARLY DIAGNOSIS AND TREATMENT OF CANCER:
HEAD AND NECK CANCER 2010 by Saunders,
Antioxidant mainly increases immunity, controls free radicals mediated cell disturbances, maintains membrane integrity, inhibit cancer cell growth and cytotoxicity.
Hello, Antioxidants & Oral mucosal lesions: The evidence in support of a chemopreventive role for the so-called antioxidant nutrients, β- carotene and vitamin E, against oral cavity cancer. In several epidemiologic studies, low intakes of vitamin E, carotenoids, or both have been associated with a higher cancer risk.
Antioxidants help in preventing the excessive release of the reactive oxygen species which are responsible for damage to the oral tissues leading to conditions like leukoplakia, oral submucous fibrosis,lichenplanus to name a few. By administering antioxidants the lesions heal and can be prevented from becoming malignant.
Antioxidants with Topical corticosteroids and Retinoids play an important role in treatment plan for POTENTIALLY MALIGNANT DISORDER S in oral cavity....
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