What is the relationship between anticoagulants used in blood collection tubes and lactate dehydrogenase (LDH) activity in plasma or serum samples?

Claire Ann Bernal Sadim @Claire-Ann-Sadim

09 April 2024 1 8K Report

This question is derived from an article entitled "Underfilling of vacuum blood collection tubes leads to increased lactate dehydrogenase activity in serum and heparin plasma samples" by Neuwinger et. al. in 2019. I want to know how certain anticoagulants affect the lactate dehydrogenase activity in plasma or serum samples.

Micol Macasil

The preservation of enzyme activity is the main connection between the anticoagulants used in blood collection tubes and the lactate dehydrogenase (LDH) activity in plasma or serum samples. Cells contain an enzyme called LDH, whose activity can be evaluated in serum or plasma samples to determine whether a disease or tissue damage has occurred.

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