What is the reason for cells having two different pathways for glutamate metabolism? Does one pathway predominate over another?

14 February 2020 0 7K Report

Glutamate is converted to alpha ketoglutarate in mitochondria through either Glutamate dehydrogenase ( GDH) or Glutamate Pyruvate transaminase (GPT2). What is the relative contribution of each pathway towards glutamate breakdown ? Does one pathway predominate over the other depending on tissue type , or do they work simultaneously?

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