Although seronegative RA is traditionally regarded as less severe compared to seropositive RA, it can progress as quickly as in seropositive RA. Thus treatment for both should be started as soon as possible and escalated in a timely manner to get fast control.
Determining a prognosis or outcome for any rheumatoid arthritis (RA) patient is difficult; seronegative patients are no different. The disease itself may start out with mild symptoms and involve into more severe ones that make treatment more difficult. Seronegative patients are often regarded as having a milder set of symptoms compared to seropositive . Generally, seronegative patients don’t develop rheumatoid nodules, which are commonly displayed in seropositive patients. This is never a certainty, however, and each patient’s individual symptoms and disease progression will differ. Treatments for seronegative RA are approached the same way as seropositive patients. The goal of treatment is to mitigate pain and prevent the disease’s progression. Focusing on reducing pressure and deterioration of joints is very important in delaying the disease. Treatment should be started as early as possible to prevent the disease from worsening.