It all depends upon what you intend to use the primers for. Each method is going to have its own design parameters, such as for amplifcation vs sequencing vs mutagenesis etc. Generally if you look at the instruction manuals for different kits to do the experiment you wish to do, they will explain the optimal design of primers for that application.

To add to Michael's point above, what is your application? Genotyping is different to expression analysis. MicroRNA primers are different to coding gene mRNA primers etc. There is no one-size-fits-all answer here.

Dear Siddhanath Shendekar

i'm agree with the previous answers. There is not an universal method since it depends from the application for which you will use your primers

for example:

1) PCR amplification and gene cloning

2) Genotyping and/or serotyping

3) dna sequencing

4) Q-PCR or RT-PCR

at the following link you can find some guidelines for the example 1)

https://www.blogger.com/video.g?token=AD6v5dzxz85z69as_qBJCTiisMtVv4q-Q0ChLHJHqSwNRA_FWtuB9p36qi4nQxd4b3OB2cxClbV6BmNDgkIdwfDUZqcDdOrGBSsjcuGTQKHAIEJPIrzIbIxwHrRRfZQf_UG0xZwwe2I

best regards

Manuele