Looks like your ligand is drifting across the periodic boundary of your box

https://en.wikipedia.org/wiki/Periodic_boundary_conditions#:~:text=In%20molecular%20dynamics%20simulations%20and,a%20bath%20of%20explicit%20solvent.

Therefore it is drifting out of the top in your second movie to apparently jump to the bottom

Dear Annemarie Honegger

Thank you for your response,

Do you have any insight on how I can correct this as I visualize my trajectory?

Thank you in advance

You need to specify -nojump as you convert the trajectory file

e.g.

https://manual.gromacs.org/documentation/2018/onlinehelp/gmx-trjconv.html

"Option -pbc sets the type of periodic boundary condition treatment:

...

nojump checks if atoms jump across the box and then puts them back. This has the effect that all molecules will remain whole (provided they were whole in the initial conformation). Note that this ensures a continuous trajectory but molecules may diffuse out of the box. The starting configuration for this procedure is taken from the structure file, if one is supplied, otherwise it is the first frame.

..."

also

https://docs.mdanalysis.org/stable/documentation_pages/transformations/nojump.html