Many study suggest that elevated liptin level in obese individuals cause hypertension, l may disagreed with them, it has protection mechanism against hypertension. As it's a potent vasodilator
please look in this link , it will help you
Article Positive Relationship Between Plasma Leptin Level and Hypertension
Leptin has been shown to influence nitric oxide production and natriuresis, and along with chronic sympathetic activation, especially to the kidney, it may lead to sodium retention, systemic vasoconstriction, and blood pressure elevation. Consequently, leptin is currently considered to play an important role in the development of hypertension in obesity.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1993994/
Please read: Adenovirus-mediated leptin expression normalises hypertension associated with diet-induced obesity, J Neuroendocrinol. 2010;22(3):175-80. In this study, high-fat diet induced obesity and high blood pressure, which was accompanied by a rise in plasma leptin level. However, the hyperleptinemia was insufficient to counterbalance either hypertension or other metabolic changes. Adenoviral leptin gene therapy that boosted circulating leptin level further up, normalized blood pressure in the model. Article Adenovirus-Mediated Leptin Expression Normalises Hypertensio...
It's an interesting subject to handle. However, Leptin has some hunger inhibiting effect and can cause profound increase in food intake after wait loss.
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