Actually as per BCS classification system acyclovir 200 mg tablet consider as BCS class III and 800 mg tablet Class IV , is there any paper proved as 800 mg tablet is has less solubility?
Stanton de Riel
Since the oral bioavailability of drug is only 10-20% anyway, the FDA is just saying that you have maxxed out the intestinal uptake with 200 mg. Since sodium acyclovir is soluble to 50 mg/ml in water (IV stock solution preparation), obviously it's not a solubility issue per se (i.e., if you don't dissolve all 800 mg in your medium, it won't matter in terms of amount absorbed in vivo).
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