Thanks Baumer. Yeah, I use staurosporine routinely to induce apoptosis. Staurosporine induces apoptosis via intrinsic pathway. I am looking for some apoptosis induce that can induce apoptosis via extrinsic pathway. If TNF-alpha is not a good inducer then could you suggest me some alternative apoptosis inducer that can induce apoptosis via extrinsic pathway?