Dear Arsalan,

Please read the following text:

Materials & Methods

A Randomized controlled trail was conducted in the Dept. of Pharmacology, Dr Pinnamaneni Siddhartha Institute of Medical Sciences and Research Foundation (Dr.PSIMS), Chinoutapalli, Krishna District, Andhra Pradesh with the institutional ethical committee clearance. Total rats were randomly divided into 4 groups, 6 rats in each group. First group of rats were considered as controls and treated with 0.2 ml normal saline. Second group were considered as test drug and treated with Diacerein at doses of 1.4mg/kg, 2.8mg/kg, and 4.2 mg/kg body weight. Third group were considered as standard 1 and treated with Etoricoxib at doses of 5mg/kg, 10mg/kg and 15 mg/kg. , Fourth group were considered as standard 2 and treated with Meloxicam at doses of 0.214mg/kg, 0.428mg/kg, and 0.642 mg/kg. Tail flick time was considered as reaction time. Normal reaction time was noted for 5 times in each animal before stating the experiment. Average of 5 readings taken as mean reaction time at 0 mins. After recording of normal reaction time normal saline was administered (intra peritoneally) to control group, Diacerein was administered (intra peritoneally) to test group, Etoricoxib was administered (intra peritoneally) to

standard 1 group, Meloxicam was administered (intra peritoneally) to standard 2 group and. Reaction time after the drug given was recorded at 5 minutes, 15 minutes and 30 minutes. All recordings were tabulated separately.

This text was taken from a publication entitled "To compare the analgesic activity of Diacerein, Etoricoxib and Meloxicam in rats by using analgesiometer "  by Dr.Neeraja.K, S.K.D.Swathi.Remella, Hanumanth N published in IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) e-ISSN: 2279-0853, p-ISSN: 2279-0861.Volume 14, Issue 10 Ver. VI (Oct. 2015), PP 11-14. To view the full publication, please use the following link:

http://www.iosrjournals.org/iosr-jdms/papers/Vol14-issue10/Version-6/C0141061114.pdf

Hoping this will be helpful,

Rafik

thanks