Biomechanics face grand challenges due to the intricacy of living things. We need multidiciplinary approach (mechanical, chemical, electrical, and thermal ) to unravel these intricacies. We need to integrate observations from multiple length scales - from organ level to, tissue level, cell level, molecular level, atomic level, and then to energy level) Over these intricacies, their dynamism, the complexity of their response makes it very difficult to correlate empirical data with theoretical models. Among these challenges, which is the most important challenge. If we solve the most important challenge, we could solve most of the other challenges easily.