How to highlight novelty in your research paper?

I have come up with a method and had written a paper on it. Paper got rejected by a journal stating that there is no theoretical novelty. I am kind of confused on why the novelty that I am able to...

28 February 2021 2,393 8 View

I have genotype gvcf of 30GB , which is causing an issue in analysis. I was wondering if there is a way to get around the size issue ?

I have a genotype gvcf of significant size, which is causing an issue in analysis. I was wondering if there is a way to get around the size issue and run the genotype gvcf in R or do I need to...

09 February 2021 4,178 4 View

Can anybody please give me idea about the complete procedure to estimate state of charge of the battery through hardware setup?

I am working on SOC estimation of battery for EV's, I want to extract the real battery data through the experiments on battery, so i want to know what exactly the equipment's i need to perform the...

22 January 2021 8,216 2 View

How stiffness matrix modification after hinge formation is done for pushover analysis?

Can anyone please explain this? How do I account for plastic hinges in my model and how do I modify the stiffness after plastic hinge is formed? Need a small example. Thank You

15 November 2020 1,967 3 View

How to analyze nominal/ordinal data in cases where you are testing multiple drugs/ infection against common risk factors?

chi-square or Fisher exact test I have a statistical question about chi-square and/or Fisher exact test. I have a cohort data studying the cause of infection in BRD with variables such as age,...

28 October 2020 2,589 1 View

What vehicle to be used for the drug loaded nano chitosan-pectin nanoencapsulated powder?

I want to know about vehicle or solution that I can use for the dosing of drug loaded nanochitosan-pectin nanoencapsulated powder?

25 October 2020 3,890 3 View

How to use 5 by 5 or 7 by 7 kernel size for a deep learning network with 3 by 3 kernels?

I am using a U-Net architecture with Xception net as encoder . The visual area of the segmentation mask is very small and after training, it is giving a lot of false positives. I am thinking of...

20 September 2020 1,968 2 View

How to model hysteresis property of concrete in abaqus?

I want to model rc element subjected to cyclic loading, How do I enter hysteresis data in the material model? I want to use Mander's 1988 model to get data for concrete. I dont know how to enter...

06 September 2020 7,651 3 View

Which fractional operator (with singular/nonsingular kernels, local, discrete, etc.) is more effective for modeling biological systems/processes?

To identify the most important fractional operator which is physically significant for the modeling of biological systems/processes (Viral dynamics, Fluid dynamics, Calcium dynamics and so on) to...

08 July 2020 8,146 3 View

Column chromatography. Problems with pH - why?

What if in column chromatography with solution (neutral pH) acidic pH is observed and remains along the whole process? What went wrong and what to do with this?

10 April 2020 5,587 4 View

Can we classify HV and LV lines based on line length?

I have dataset which shows the length of power lines. I need to classify the lines based on the line length. Is there a rule to classify the High voltage (HV) and low voltage (LV) lines based on...

03 March 2021 4,116 4 View

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02 March 2021 3,060 3 View

Issues with Permeabilization during Flow Cytometry?

Hello Everyone. Currently I am working to characterize macrophages in the myocardium after ischemia-reperfusion injury in rats. Due to the low total cell number isolated from rat hearts I can...

01 March 2021 3,867 3 View

Which cell line should we use to perform biological dosimetry experiments?

We are preparing some experiments based on irradiating cells under different conditions in order to evaluate the effects in terms of DNA damage, genetic expression, etc. As our project is...

01 March 2021 3,355 3 View

What is the most reliable source to get Impact factor of journals?

Source to get Impact factor of journals

01 March 2021 6,654 2 View

Is it possible for two human neuronal cell lines to have different gene sequence for the same protein?

I am looking at the ATP1A2 (Sodium/Potassium ATPase alpha subunit 2) in two human neuronal cell lines. Expression levels of this protein seems to be almost equal when detected by one antibody....

01 March 2021 3,607 3 View

Is CD44 degraded in lysosome together with hyaluronan after CD44 mediated endocytosis of hyaluronic acid?

Also when RHAMM binds hyaluronic acid, they get internalized, will RHAMM also be degraded? Or both CD44 and RHAMM will be transferred back to the cell membrane? Asking for breast cancer cell line...

01 March 2021 8,169 2 View

Do you need the CMV enhancer before the CMV promotor for a proper function of CMV on the gene that follows?

I'm a student and I have to produce a cell line with a knockin for the NRF2 gene with GFP. I have to put a promotor in front of the GFP because the gene will be too far away from the promotor of...

28 February 2021 7,127 2 View

What could be some reasons why unstimulated monocytes are getting activated?

Im doing PBMC isolation -> CD14+ enrichment using magnetic beads -> stimulation setup. My negative control is just cells in cRPMI but they seem to get activated over and over again.

28 February 2021 7,883 3 View

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28 February 2021 9,936 2 View