In the NETosis the primary granules present inside neutrophils are ruptured causing the release of NE and MPO that assist producing NETs inside neutrophil nucleus. My question is how excatly this azeurophilic granules are releasing these proteases? some paper says it is directly fusing with neutrophil nucleus and some say both NE and MPO has nuclear localization signal.
I want to know by what exact molecular mechanism is causing this release. Is there any surface receptor present on primary granules? or if it is directly fusing with neutrophil DNA which proteins and receptors are involved?
I hope the below files can help you:
https://pubmed.ncbi.nlm.nih.gov/33202203/#:~:text=NETosis%20is%20a%20program%20for,physiological%20stimuli%20can%20cause%20NETosis.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7590568/
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