Hi ,
What is the methotrexate solvent. I try to use methanol, DMSO and DMF. But methotrexate was disolve very slightly in these solvent. Methotrexate is a hydrophobic anticancer drug. I can not use acidic solvent. Because another material in my experimental protocol is sensetive to acidic condition.
And I can not use very toxic solvent because I work on drug delivery system.
Thank you everybody
Dear Dr Shakeran
Please use PBS as a solvent. MTX injection, USP at 25 mg/ml could be diluted in PBS to 0.2 mg/ml for injection.
The solubility of methotrexate USP in propylene glycol-water mixtures was found to vary from 0.1752 0.0048 mg/ml in 20% v/v aqueous propylene glycol to 1.4567 0.0363 mg/ml in 80% v/v aqueous propylene glycol.
Dear Mr Ziaee, thank you for your suggestion. I need to disolve the methotrexate in solvent to 1mg/ml for delivery of that by nanoparticle.
Dear Mr Blasko,thank you so much. I want to delivery of methotrexate by nanoparticle with hydrophobic nature. Is it remain in hydrophobic nature if I adding propylene glycol ?
The main problem is the stability in the nanoparticles. For this you need to do a pH-Stability profile of the formulations between 5-8 in buffer solutions.
Methotrexate is an antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities.
It's a drug to treat some cancers and ectopic pregnencies. Here is tis structure
Hi, thank you so much
Ok, in your opinion, can I use the N-methyl pyrrolidon as a methotrexate solvent?
methotraxate is soluble in organic solvents such as DMSO and PBS, PH is 7.2 solubility is approximately 1mg/ml
I think its need more alkaline for more solubility
Hi,
The solubility of MTX in PBS, pH 7.2, is approximately 1 mg/ml. But you can not storing the aqueous solution for more than 1 day.
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