Recent reports shows association between Vit A diffiency and T2D. What is the most likely mechanism of action?
Are you sure you ment vitamin A? Or do you mean vitamin D. For the latter there are several possible relations.
I found also some literature about an association of vitamin A and DM in a review
The Journal of Nutrition Supplement: Biomarkers of Nutrition for Development (BOND) Expert Panel Reviews, Part 4
Biomarkers of Nutrition for Development (BOND)—Vitamin A Review
Sherry A Tanumihardjo, Robert M Russell, Charles B Stephensen, et al
J Nutr 2016;146(Suppl):1816S–48S.
If there is a mechanism, it could be based on the immune system supporting effects of vitamin A as well as vitamin D.
Dear@Nabil
Not exactly sure but i guess vitamin A helps in some way to preserve the beta cells and thus provides some degree of protection against beta cell dysfunction.
Also not sure whether this is the cause or effect relationship but still few studies have shown association of vitamin A and hyperglycemeia in relation to beta cell function.
Sharing below:
Article Vitamin A deficiency in mice alters host and gut microbial m...
Article Vitamin A Deficiency Causes Hyperglycemia and Loss of Pancre...
Article Vitamin A Deficiency Impairs Fetal Islet Development and Cau...
I sincerely hope these few studies, including the one carried out on mice should help you.
Warm regards
this reference might also be useful to get your answer "Kelly, Gregory M., and Thomas A. Drysdale. "Retinoic acid and the development of the endoderm." Journal of Developmental Biology 3, no. 2 (2015): 25-56."
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