What is the meaning of lower spleen weight in toxicity experiments?

01 October 2017 1 4K Report

In the acute toxicity trials of some pesticides, an increase in the weight of various organs such as the heart, lungs and liver occurs, but the weight of the spleen decreases. What does this mean?

Eric B. Brandt

Let me guess: inflammation in numerous organs leads to massive recruitment of blood cells into inflamed organs. Bone marrow can't keep up. Blood cells get depleted and the spleen that filters the blood now contains significantly fewer blood cells. As a result the spleen weight decreases.

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