Hi Colleagues,
Any experience with PLGA injections into mice?
What is the maximal concentration I can inject without blocking a 22G needle?
I often see data with people injecting 10 mg, can I go up?
Thank you very much for your help with this pure technical question.
Sarah Berndt
Hi Vamsi,
thank your for your answer. I am using microspheres of PLGA loaded with lipids and re-suspended in an organic carrier. I want to inject more than 10 mg. Just wondering what is the technical limit in regards to a higher concentration?
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Sarah Berndt
Hi Vamsi,
In my protocol I have to inject 100 microl of 50 mg/ml in CMC 2%. I already tested the dilution and it is like a thick paste, that could only be injected with a 18G needle!!
should I increase the concentration of CMC?
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