There are so many researchers developing inhibitors for tumor.
For those tumor that has a single and specific shape, what is the main treatment? Isn't the tumor removal surgery much more faster than those drug inhibitors?
I know most of time it is hard to clean all the cancer cells by surgery, by you can do surgery first and then use those drug inhibitors to clean the rest of cells to prevent relapse. I'm just thinking those inhibitors work slower than the surgery and would cause other side effects. And also, tumor cells are smart, they can always develop resistance against inhibitors.
I'm wondering if removal surgery is the main treatment for this kind of cancer.
I think surgery may be helpful if the tumor cells are localized at a distinct anatomical site.
I think that the problem of surgery is the localizing tumor cells at a distinct anatomical site. Really, the accelerating development of cancer cells' proliferative processes are the great obstacle for efficiently targeting nuclear proliferative processes in modern chemotherapy with cytotoxic drugs. Unfortunately, the modern medicine does not accept yet chance to target mechanism of cancer metabolism which is expressed in Warburg effect. Such approach to cancer treatment can help of efficient chemotherapy with cytotoxic drugs.
[see 1. Ponizovskiy M.R., (2012), The detailed description mechanisms of the herbs extracts operations in the new method cancer disease treatment via rearrangement of metabolism from pathologic development into normal development, Journal of Clinical Trials, v. 2, Issue 4, 1 – 10, doi:10.4172/2167-0870.1000124.
2. Ponizovskiy M.R., (2014), Cancer therapy via targeting Warburg effect leads to cancer metabolism depression that promotes efficient treatment with small dosage cytotoxic drugs, American Journal of Cancer Science, Volume 3, № 1, 30 – 53 (24 pages).
3. Ponizovskiy M.R., (2015), Cancer therapy leading to state of cancer metabolism depression for efficient operation of small dosage cytotoxic drugs, Journal of Cancer Research & Therapy, 3(3), 38 – 55, doi: 10.14312/2052-4994.2015-7.
4. Ponizovskiy M.R., (2016), The advantage of cancer therapy with targeting Warburg effect mechanism in new possibility cancer disease treatment, The Abstract at 5-th International Conferenca and Exhibition of Call and Gene Therapy, May 2016, USA]
It depends on the tumor as well as on it's anatomical localisation and on the patient's condition. Not every tumor can be removed easily. Sometimes you can only remove a part of a tumor without removing too much “normal“ tissue. In addition malignant tumors invade into organ stroma so you probably cannot see whether you have removed all the tumor cells.
Usually there is a combination of surgery and chemotherapy to make sure, all, the tumor cells have been removed.
A very simple and elegant answer from Elena. To elaborate on what she pointed out, Surgery, Chemotherapy and Radiotherapy are the main 'cytocidal' treatments, with Hormone and Immuno therapies as modulating ones. Selection of the single/combined modality is influenced by many factors such as site, histology, grade, stage, etc., etc.
Narayanan
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