Organic solvent for trehalose?

I am looking for an organic solvent for trehalose. DMSO works, methanol works, like ethanol, but both are not suited for the rest of my process. Any ideas or exprience here?

04 August 2020 6,984 3 View

Elution of an antibody on a peptide immobilized column did not work?

I am very disappointed. I coupled a peptide with an N-terminal cysteine on a sulfolink column. HPLC shows that the peptide immobilization was almost complete. After cyclisation of the serum the...

25 May 2020 1,265 8 View

Hi! Can anyone show me how to calculate the total anthocyanins content using the OD at 545, 535 and 515 nm?

27 January 2017 7,419 3 View

Would you suggest any software executing ANN (MLP type) where connections between neurons (in consecutive layers) can be separately defined by user?

10 October 2016 3,464 7 View

What are the specific possible biases involved in having one coder in a qualitative analysis?

27 June 2016 998 4 View

Is there a reference article documenting the preferred imaging modes in oncology?

I would like citing a reference in a manuscript about the most used imaging modalities in oncology. Did somebody could provide me with a pointer?

17 August 2015 5,791 3 View

What is a clear definition for radiomics?

I am looking for a clear definition of "Radiomic". According to different papers from: Kuo, 2007; Lambin. 2012; aerts. 2014; singanamalli, 2014 and some others, I am not sure if the concept of...

15 February 2015 6,726 8 View

How can I compute the limit of agreement with Bland Altman featuring heteroscedasticity?

I am analysing repeated measurement of ratio-scaled data. For doing that I rely on Bland Altman analysis. The common case where Limit of Agreement is horizontal can be adressed by most of the...

20 February 2014 4,709 2 View

How to manage Bland Altman analysis with more than one couple of measurements?

I consider three readers circularly involved in Bland-Altman 2-by-2; threfore I obtained 3 Bland-Altman analysis with corresponding Limit of Agreement (and Confidence Interval). In order to get...

16 January 2014 9,164 6 View

Good sites to recruit survey participants on a grad school student budget?

Any good recommendations for participant recruitment for online surveys on a grad school student budget?

02 March 2021 4,293 4 View

How to code open-ended questions in SPSS?

Hello all, In SPSS I am going to code 2 open-ended questions. I have already read all the answers and I made a list of the most important categories to which I can code the answers. This question...

02 March 2021 1,757 4 View

Does Napabucasin soluble in dichloromethane and in ethanol?

I need to prepare a solution of Napabucasin (inhibitor of cancer cell stemness) in dichloromethane. The drug is expensive, so maybe somebody already tried to do it. If it is soluble, what is the...

02 March 2021 9,945 3 View

Could you please recommend some good journal that accept very long revie papers (approximately 6000+ words) in neurosurgery, cancer biology ?

Could you please recommend some good journal that accept very long revie papers (approximately 6000+ words) in neurosurgery, cancer biology ?

01 March 2021 8,087 3 View

Which cell line should we use to perform biological dosimetry experiments?

We are preparing some experiments based on irradiating cells under different conditions in order to evaluate the effects in terms of DNA damage, genetic expression, etc. As our project is...

01 March 2021 3,355 3 View

Is CD44 degraded in lysosome together with hyaluronan after CD44 mediated endocytosis of hyaluronic acid?

Also when RHAMM binds hyaluronic acid, they get internalized, will RHAMM also be degraded? Or both CD44 and RHAMM will be transferred back to the cell membrane? Asking for breast cancer cell line...

01 March 2021 8,169 2 View

How to eliminate Steady state error from Reinforcement learning genetic algorithm code?

The following code (see 1st 2 images attached) is used to produce PID controller values that are designed to control the system (G). The code finds the PID controller values (noted as k) by using...

28 February 2021 6,560 14 View

How to compare 2 samples recruited with different sampling methods?

If I want to compare characteristics of 2 groups of patients, one group is recruited from a random sample of the general public while another group is from a sample with a fixed gender (male to...

26 February 2021 3,526 3 View

How could I process data in RCT to include it in meta-analysis?

I'm in the process of doing a meta-analysis and have encountered some problems with the RCT data. One of my outcom is muscle strength. In one study, I have three different measurements of muscle...

25 February 2021 7,603 3 View

Errors in DNA sequences?

I am trying to better understand the scope of DNA replication and sequencing errors, e.g. 1. I have seen similar error rates of 10e4 to 10e5 for cell & instrumental DNA replication,...

24 February 2021 4,397 3 View