What is the intracellular distribution of Matrix Metalloproteinase (MMP)-9 in fast motor neurons (if possible, which organelle)? Do they found in the axon terminal?
Additionally, do microglia express MMP-9 (it seems to me that I found some "localized" expression)?
I have a picture for your references (where green is the MMP-9 immunopositive reactions; red is IBA-1).
William Rate
It appears that primary murine microglia produce MMP-9 precursors (proMMP-9) when exposed to vitronectin and fibronectin.
(http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3345906/)
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Qing-Rong Liu
Check transcriptome data of purified microglia for MMP-9 that is more peripheral than CNS.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840123/
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