Dear Tareq,

Take a look at this synthesis:

https://link.springer.com/content/pdf/10.1007%2F978-94-007-7500-8.pdf

Dear Abdenour,thankyou for reply ,nickel is not always beneficial ,but it can be toxic and harmful ,see this statements,

ckel can enter your body when you breathe air containing nickel, when you drink water or eat food that contains nickel, and when your skin comes into contact with nickel. If you breathe air that contains nickel, the amount of nickel you inhale that reaches your lungs and enters your blood depends on the size of the nickel particles. If the particles are large, they stay in your nose. If the particles are small, they can enter deep into your lungs. More nickel is absorbed from your lungs into your body when the nickel particles can dissolve easily in water. When the particles do not dissolve easily in water, the nickel may remain in your lungs for a long time. Some of these nickel particles can leave the lungs with mucus that you spit out or swallow. More nickel will pass into your body through your stomach and intestines if you drink water containing nickel than if you eat food containing the same amount of nickel. A small amount of nickel can enter your bloodstream from skin contact. After nickel gets into your body, it can go to all organs, but it mainly goes to the kidneys. The nickel that gets into your bloodstream leaves in the urine. After nickel is eaten, most of it leaves quickly in the feces, and the small amount that gets into your blood leaves in the urine.

It can be toxic

Many adverse effects are described in literature

Dear piston,thankyou as you said many literature said its toxic,no one hraring things and we shall give is still toxic ,

Nickel is essential for microorganisms that colonize the human guts.

Article Nickel and Human Health

Maybe in the process of regulating blood sugar???

Dear Tareq Abdhilkadhim Naser Alasadi

Nice Question.

This is an interesting recent (2019) article in Nature. Hope its appealing:

https://www.nature.com/articles/s41598-019-50027-0

Nickel chelation therapy as an approach to combat multi-drug resistant enteric pathogens

Nickel can be used as bio markers, bi markers of exposure Both plasma and urine concentrations of nickel are useful biomarkers of nickel inhalation exposure on a group basis (33). The correlation between exposure and biological values on an individual basis is low and significant only in some investigations involving exposure to soluble compounds. The levels in plasma and urine are highly dependent on the nickel species in air. High air levels of oxidic and sulfidic nickel give relatively lower plasma and urine values than a corresponding level of soluble chlorides or sulfates, but higher values in the nasal mucosa and probably also in the lungs (possible target organs) (45

There is a book available entitled "Biochemistry of Nickel". It was written by Robert P Hausinger and was published by Springer in 2013. You should also search the literature for publications by Rudolf Kurt Thauer who made very exciting investigations in this field.

Nickel is important element,ickel is a mineral. It is found in several foods including nuts, dried beans and peas, soybeans, grains, and chocolate. The body needs nickel, but in very small amounts. Nickel is a common trace element in multiple vitamins.

Nickel is used for preventing nickel levels in the blood from getting too low (nickel deficiency). It is also used for low levels of healthy red blood cells (anemia) due to iron deficiency and treating weak and brittle bones (osteoporosis), but there is no good scientific evidence to support these uses.